ASICs and cardiovascular homeostasis

Cardiovascular endothelins: essential regulators of cardiovascular homeostasis.

The endothelin (ET) system consists of 3 ET isopeptides, several isoforms of activating peptidases, and 2 G-protein-coupled receptors, ETA and ETB, that are linked to multiple signaling pathways. In the cardiovascular system, the components of the ET family are expressed in several tissues, notably the vascular endothelium, smooth muscle cells, and cardiomyocytes. There is general agreement tha...

in 1 . ZERO GRAVITY AND CARDIOVASCULAR HOMEOSTASIS

Cyclophilin A in cardiovascular homeostasis and diseases.

Vascular homeostasis is regulated by complex interactions between many vascular cell components, including endothelial cells, vascular smooth muscle cells (VSMCs), adventitial inflammatory cells, and autonomic nervous system. The balance between oxidant and antioxidant systems determines intracellular redox status, and their imbalance can cause oxidative stress. Excessive oxidative stress is on...

ASICs and mammalian mechanoreceptor function

It is well established that some members of the Deg/ENaC super family of amiloride sensitive ion channels can participate directly in the transduction of mechanical stimuli by sensory neurons in invertebrates. A large body of work has also implicated the acid sensing ion channels family (ASIC1-4) as participants in regulating mechanoreceptor sensitivity in vertebrates. In this review we provide...

ASICs, Processors, and Configurable Computing

represents a new computational middle ground that fills the existing void between conventional microprocessors and ASICs. This point of view is based upon the observation that FPGAs share some similarities with both processors and ASICs. FPGAs are seen as similar to processors because they are customized in the field by the end-user by downloading configuration data into the device. They can al...